Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate is an organic boron compound having the formula C7H7BF3OK. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate as a white crystalline solid.
-Melting point: Its melting point is generally between 130-135 degrees Celsius.
-Solubility: The compound can be dissolved in water and organic solvents.
Use:
- Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate is an important organoboron reagent, which can be used in organic synthesis reactions. It is commonly used in the preparation of catalysts and in the synthesis of organic molecules.
-It exhibits good reactivity as a potassium salt in Suzuki-Miyaura coupling reactions, and can catalyze the carbon-carbon bond formation reaction between aromatic compounds.
Preparation Method:
The preparation method of Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate usually involves the following steps:
1.3-hydroxymethylbenzaldehyde is reacted with trifluoroborate ester to obtain 3-(trifluoroborate) benzyl alcohol.
2.3-(trifluoroborate) benzyl alcohol reacts with potassium hydroxide to generate Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate.
Safety Information:
Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate have no obvious safety problems under correct use and storage conditions. However, the following safety practices still need to be followed:
-Avoid direct contact with skin and eyes. If contact occurs, immediately flush the affected area with plenty of water and seek medical assistance.
-Wear appropriate protective gloves and eye/face protection during operation.
-When storing, the Potassium (3-(hydroxymethyl)-phenyl)trifluoroborate should be stored in a dry, well-ventilated place, and stored separately from the combustion and oxygen.
Please note that the above information is for reference only. In the actual application process, safety measures should be taken according to the specific situation, and it is recommended to operate in a qualified chemical laboratory.